Mackinnon A M
Biochim Biophys Acta. 1976 Sep 24;444(2):613-7. doi: 10.1016/0304-4165(76)90405-0.
Three days after selective biliary obstruction in rats, bile output from the single unobstructed lobe was equivalent to the usual output from three hepatic lobes. There was a significant decrease in the level of the hepatic microsomal mixed function oxidase system components, cytochrome P-450 and NADPH-cytochrome c reductase. The levels observed after three days were reduced to an equivalent extent in both selectively obstructed and unobstructed lobes, and corresponded to the level seen after total biliary obstruction. Hepatic bromosulphothalein Tm was significantly reduced three days after selective obstruction, but did not differ from normal after six days. These data indicate that a factor generated in response to biliary obstruction acts to lower hepatic mixed function oxidase system components and increase bile flow in functioning hepatic tissue.
大鼠选择性胆管梗阻三天后，单个未梗阻肝叶的胆汁分泌量相当于三个肝叶的正常分泌量。肝微粒体混合功能氧化酶系统成分细胞色素P-450和NADPH-细胞色素c还原酶的水平显著降低。三天后，在选择性梗阻和未梗阻的肝叶中观察到的水平均降低到相同程度，且与完全胆管梗阻后的水平相当。选择性梗阻三天后，肝溴磺酞钠Tm显著降低，但六天后与正常水平无差异。这些数据表明，胆管梗阻引发产生的一种因子可降低肝混合功能氧化酶系统成分，并增加有功能的肝组织中的胆汁流量。
