Amitai Y, Regev M, Arad I, Peleg O, Boehnert M
Department of Pediatrics, Hadassah University Hospital Mount Scopus, Jerusalem, Israel.
J Perinat Med. 1993;21(3):189-94. doi: 10.1515/jpme.1993.21.3.189.
The efficacy of multiple dose oral activated charcoal (OAC) therapy for neonatal hyperbilirubinemia was prospectively studied in 30 jaundiced newborns receiving phototherapy, randomly assigned to a study group (n = 14) or control group (n = 16). The study group received OAC before meals with a total amount of 8.5 +/- 0.85 gms (M +/- SEM). Serum bilirubin levels upon initiation of phototherapy were (M +/- SEM) 265 +/- 8 and 253 +/- 4 mumol/L respectively. After 24 hours there was no significant decrease in serum bilirubin levels in the control group (M +/- SEM = 240 +/- 8 mumol/L) but bilirubin levels of the study group decreased (M +/- SEM = 235 +/- 7 mumol/L, p < 0.02). At 48 hours serum bilirubin levels were significantly lower than baseline values in both groups. However, the decline in bilirubin levels in the study group (M +/- SEM = 56 +/- 10 mumol/L) was greater than that of the controls (M +/- SEM = 21 +/- 10 mumol/L p < 0.02). Oral activated charcoal seems to be an effective adjunct to phototherapy in the treatment of neonatal hyperbilirubinemia.
对30例接受光疗的黄疸新生儿进行前瞻性研究，以探讨多剂量口服活性炭（OAC）治疗新生儿高胆红素血症的疗效。这些新生儿被随机分为研究组（n = 14）或对照组（n = 16）。研究组在饭前服用OAC，总量为8.5±0.85克（均值±标准误）。光疗开始时血清胆红素水平分别为（均值±标准误）265±8和253±4μmol/L。24小时后，对照组血清胆红素水平无显著下降（均值±标准误=240±8μmol/L），但研究组胆红素水平下降（均值±标准误=235±7μmol/L，p<0.02）。48小时时，两组血清胆红素水平均显著低于基线值。然而，研究组胆红素水平下降幅度（均值±标准误=56±10μmol/L）大于对照组（均值±标准误=21±10μmol/L，p<0.02）。口服活性炭似乎是治疗新生儿高胆红素血症光疗的有效辅助手段。
