通过激光多普勒血流仪评估血小板活化因子和组胺对滑膜血流的影响。
Platelet activating factor and histamine effects in synovial blood flow evaluated by laser-Doppler flowmetry.
作者信息
Rocha F A, Jancar S, Fraga C A, Timo-Iaria C, De Brum-Fernandes A J
机构信息
Department of Medicine, University of São Paulo, Brazil.
出版信息
J Rheumatol. 1993 Aug;20(8):1374-7.
OBJECTIVE
To investigate platelet activating factor (PAF) and histamine effects in synovial circulation of rabbits.
METHODS
A laser-Doppler flowmeter was adapted to study the synovial blood flow. Either PAF or histamine were infused in the first femoral artery branch. The effects of PAF and histamine antagonists as well as of inhibitors of cyclooxygenase products were evaluated.
RESULTS
PAF induced a vasoconstriction in synovial circulation, which was inhibited by the PAF antagonist, WEB 2170, a cyclooxygenase inhibitor, indomethacin or a thromboxane synthesis inhibitor, dazmegrel. Histamine induced vasoconstriction in the synovial vessels. Promethazine not only inhibited this vasoconstriction but also induced a vasodilation, that was blocked by a combined treatment with promethazine and cimetidine. Pretreatment with WEB 2170 did not interfere with histamine effect.
CONCLUSIONS
Our data indicate that PAF induces vasoconstriction in synovial blood flow through a receptor mediated mechanism and that thromboxane is involved in this effect. Histamine induces constriction or dilation in synovial vessels, through action on H1 or H2 receptors, respectively. This effect is not dependent on PAF.
目的
研究血小板活化因子（PAF）和组胺对兔滑膜循环的影响。
方法
采用激光多普勒血流仪研究滑膜血流。将PAF或组胺注入股动脉第一分支。评估PAF和组胺拮抗剂以及环氧化酶产物抑制剂的作用。
结果
PAF引起滑膜循环血管收缩，PAF拮抗剂WEB 2170、环氧化酶抑制剂吲哚美辛或血栓素合成抑制剂达唑麦角可抑制这种收缩。组胺引起滑膜血管收缩。异丙嗪不仅抑制这种血管收缩，还引起血管舒张，联合使用异丙嗪和西咪替丁可阻断这种舒张。用WEB 2170预处理不影响组胺的作用。
结论
我们的数据表明，PAF通过受体介导机制诱导滑膜血流血管收缩，血栓素参与此效应。组胺分别通过作用于H1或H2受体诱导滑膜血管收缩或舒张。此效应不依赖于PAF。
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