Cheung A T, Moss R B, Kurland G, Leong A B, Novick W J
Department of Medical Pathology, University of California, Davis School of Medicine, Sacramento.
J Med Primatol. 1993 Jun;22(4):257-62.
We have recently established a rhesus monkey model of chronic Pseudomonas aeruginosa (PA) endobronchitis by bronchoscopic instillation of PA-embedded agar beads. All experimental animals developed chronic neutrophilic endobronchitis similar to chronic PA endobronchitis in cystic fibrosis (CF). Histopathologic studies further confirmed similarities to chronic PA endobronchitis in CF, including marked peribronchial inflammation, epithelial damage, presence of degraded cilia and ciliary abnormalities, appearance of PA bacterial clusters, mucosal hyperplasia, goblet cell hypertrophy/hypersecretion, airway obstruction, alveolar abnormalities, bronchiectasis, and fibrosis.
我们最近通过支气管镜滴注包埋铜绿假单胞菌（PA）的琼脂珠建立了恒河猴慢性支气管内膜炎模型。所有实验动物均发生了慢性嗜中性粒细胞性支气管内膜炎，类似于囊性纤维化（CF）中的慢性PA支气管内膜炎。组织病理学研究进一步证实了与CF中慢性PA支气管内膜炎的相似性，包括显著的支气管周围炎症、上皮损伤、纤毛降解和纤毛异常的存在、PA细菌簇的出现、黏膜增生、杯状细胞肥大/分泌亢进、气道阻塞、肺泡异常、支气管扩张和纤维化。
