Trujillo J R, McLane M F, Lee T H, Essex M
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.
J Virol. 1993 Dec;67(12):7711-5. doi: 10.1128/JVI.67.12.7711-7715.1993.
Immunologically cross-reactive proteins in the human brain that resemble the V3 loop of human immunodeficiency virus type 1 (HIV-1) gp120 have been identified. When several homogenized tissues from normal brains were used, a monoclonal antibody raised against amino acids 308 to 320 of the V3 loop reacted with three prominent human brain proteins (HBP) of 35, 55, and 110 kDa. Among the three, the 55-kDa HBP appears to be specific to the central nervous system. These results indicate that the V3 loop of HIV-1 gp120 shares an epitope with HBP. An immune response to the V3 loop that generates cross-reactive antibodies to cellular proteins may be an autoimmune mechanism by which HIV-1 can damage the central nervous system.
已在人脑中鉴定出与1型人类免疫缺陷病毒（HIV-1）gp120的V3环相似的免疫交叉反应蛋白。当使用来自正常大脑的几种匀浆组织时，一种针对V3环氨基酸308至320产生的单克隆抗体与三种主要的人脑蛋白（HBP）发生反应，它们的分子量分别为35 kDa、55 kDa和110 kDa。在这三种蛋白中，55 kDa的HBP似乎是中枢神经系统特有的。这些结果表明，HIV-1 gp120的V3环与HBP共享一个表位。针对V3环产生与细胞蛋白发生交叉反应抗体的免疫反应可能是一种自身免疫机制，通过这种机制HIV-1可损害中枢神经系统。
