Rivas D A, Chancellor M B, Hill K, Freedman M K
Department of Urology, Jefferson Medical College, Philadelphia, Pennsylvania.
J Urol. 1993 Dec;150(6):1903-5. doi: 10.1016/s0022-5347(17)35930-x.
Baclofen is a central nervous system agent that is commonly used for the treatment of muscle spasticity in spinal cord injury patients. Acute withdrawal of this medication can induce the development of neurological symptoms, including seizure disorder, psychosis, hallucinations and visual disturbances. We report 3 cases of acute central nervous system symptoms that developed in spinal cord injury patients. Each patient had been chronically maintained on a baclofen regimen to control muscle spasticity. Symptoms developed shortly after baclofen therapy was interrupted following genitourinary surgery. It is important that urologists become familiar with the symptomatology of baclofen withdrawal, the methods of its prevention and the appropriate therapy should the syndrome develop.
巴氯芬是一种中枢神经系统药物，常用于治疗脊髓损伤患者的肌肉痉挛。突然停用这种药物会引发神经症状，包括癫痫、精神病、幻觉和视觉障碍。我们报告3例脊髓损伤患者出现的急性中枢神经系统症状。每位患者长期服用巴氯芬以控制肌肉痉挛。症状在泌尿生殖系统手术后巴氯芬治疗中断后不久出现。泌尿外科医生熟悉巴氯芬戒断症状、预防方法以及该综合征发生时的适当治疗方法非常重要。
