Taguchi T, Kobayashi A, Kurata C, Tawarahara K, Yamazaki N
Third Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
Jpn Circ J. 1993 Nov;57(11):1089-96. doi: 10.1253/jcj.57.1089.
Dual-tracer imaging of the heart with 125I-metaiodobenzylguanicline (MIBG) and 201Tl can simultaneously demonstrate the distribution of sympathetic nerve endings and the underlying myocardial perfusion. A quantitative dual-tracer autoradiographic study with 201Tl and 125I-MIBG was performed to investigate changes in the distribution of cardiac sympathetic innervation with the progression of cardiomyopathy in BIO 14.6 hamsters. The distribution of 201Tl was uniform in control hamsters and BIO 14.6 hamsters at all stages of cardiomyopathy. In contrast, a reduction in MIBG accumulation occurred in the endocardial region of the left ventricular free wall and the left ventricular aspect of the interventricular septum in BIO 14.6 hamsters at 3 and 8 months of age. Thus, there was an uncoupling of the left ventricular distribution of 201Tl and 125I-MIBG in BIO 14.6 hamsters. In addition, interstitial fibrosis was increased in the interventricular septum, the subendocardial region of the left ventricular free wall, and the right ventricular wall, which were the sites of reduced MIBG accumulation. This study shows that dual myocardial imaging with MIBG and 201Tl may be useful for investigating patients with cardiomyopathy.
用125I-间碘苄胍（MIBG）和201Tl对心脏进行双示踪成像，可同时显示交感神经末梢的分布及潜在的心肌灌注情况。进行了一项使用201Tl和125I-MIBG的定量双示踪放射自显影研究，以调查BIO 14.6仓鼠心肌病进展过程中心脏交感神经支配分布的变化。在对照组仓鼠以及处于心肌病各个阶段的BIO 14.6仓鼠中，201Tl的分布是均匀的。相比之下，3月龄和8月龄的BIO 14.6仓鼠左心室游离壁的心内膜区域以及室间隔的左心室面MIBG摄取减少。因此，在BIO 14.6仓鼠中，201Tl和125I-MIBG在左心室的分布出现了解偶联。此外，室间隔、左心室游离壁的心内膜下区域和右心室壁的间质纤维化增加，而这些部位正是MIBG摄取减少的部位。这项研究表明，MIBG和201Tl双心肌成像可能有助于研究心肌病患者。
