Kurata C, Kobayashi A, Yamazaki N
Third Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
J Nucl Med. 1989 Jan;30(1):80-7.
To investigate the usefulness of myocardial scintigraphy with radioiodinated 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in cardiomyopathy, quantitative dual tracer autoradiographic study with 201Tl and [125I]BMIPP was performed in 27 cardiomyopathic Bio 14.6 Syrian hamsters and eight normal hamsters. Furthermore, 16 Bio 14.6 Syrian hamsters aged 21 days were divided into verapamil-treated (during 70 days) and control groups (respectively, n = 8), and autoradiography with 201Tl and [125I]BMIPP was performed. Quantitative autoradiography demonstrated an uncoupling of 201Tl and [125I]BMIPP distributions and a regional heterogeneity of [125I]BMIPP distribution in cardiomyopathic hamsters aged more than 2 mo, while normal hamsters showed only mild heterogeneity of [125I]BMIPP distribution without an uncoupling of tracers. Age-matched comparison between normal and cardiomyopathic hamsters (5-8 mo old) demonstrated that a difference between their [125I]BMIPP distributions are more marked than that between their 201Tl distributions. Furthermore, [125I]BMIPP visualized effects of verapamil on cardiomyopathy more distinctly than did 201Tl. In conclusion, myocardial imaging with [123I]BMIPP could be useful for investigating cardiomyopathy and evaluating the efficacy of therapeutic intervention in patients with cardiomyopathy.
为研究放射性碘标记的15 -（对碘苯基）-3 - R，S - 甲基十五烷酸（BMIPP）心肌闪烁显像在心肌病中的应用价值，对27只患有心肌病的Bio 14.6叙利亚仓鼠和8只正常仓鼠进行了用201Tl和[125I]BMIPP的定量双示踪剂放射自显影研究。此外，将16只21日龄的Bio 14.6叙利亚仓鼠分为维拉帕米治疗组（70天）和对照组（每组n = 8），并进行了201Tl和[125I]BMIPP放射自显影。定量放射自显影显示，2月龄以上的心肌病仓鼠中201Tl和[125I]BMIPP分布解偶联，且[125I]BMIPP分布存在区域异质性，而正常仓鼠仅显示[125I]BMIPP分布有轻度异质性，且示踪剂无解偶联现象。正常仓鼠与心肌病仓鼠（5 - 8月龄）的年龄匹配比较表明，它们[125I]BMIPP分布的差异比201Tl分布的差异更明显。此外，[125I]BMIPP比201Tl更清晰地显示了维拉帕米对心肌病的作用。总之，用[123I]BMIPP进行心肌成像可能有助于研究心肌病并评估心肌病患者治疗干预的疗效。
