头孢地嗪与米诺环素联合治疗血液病合并感染患者的临床疗效

[Clinical effects of a combination treatment with cefodizime and minocycline for infections in patients complicated with hematological disorders].

作者信息

Hirakawa K, Tsuda S, Misawa S, Kuzuyama Y, Nakai H, Seriu T, Takashima T, Tanaka S, Nishigaki H, Yokota S

机构信息

Third Department of Medicine, Kyoto Prefectural University of Medicine.

出版信息

Jpn J Antibiot. 1993 Aug;46(8):686-96.

PMID:8230736

Abstract

We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 with other hematological disorders. Clinical efficacies were excellent in 17 cases, good in 24 cases, fair in 2 cases, and poor in 16 cases. The efficacy rate was 69.5% (41 cases/59 cases). This treatment was also effective in 8 of 12 cases in which granulocyte counts were less than 500/microliter through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 5 cases. Mild elevations of GOT, GPT, Al-P and bilirubin were observed, but none was serious. Thus, the combination of CDZM and MINO is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.

摘要

我们评估了头孢地嗪（CDZM）与米诺环素（MINO）联合治疗67例合并血液系统疾病感染患者的临床疗效及毒性。59例患者可进行评估，其中急性白血病32例，恶性淋巴瘤15例，其他血液系统疾病12例。临床疗效为优17例，良24例，中2例，差16例。有效率为69.5%（41例/59例）。在给药过程中粒细胞计数低于500/微升的12例患者中，该治疗方法对8例也有效。未观察到主观副作用。5例实验室检查值异常。观察到谷草转氨酶、谷丙转氨酶、碱性磷酸酶和胆红素轻度升高，但均不严重。因此，CDZM与MINO联合用药是治疗合并血液系统疾病患者感染的一种有效且安全的方案。