Suzuki Y, Kuwajima I, Kuramoto K, Otsuka K
Tokyo Metropolitan Geriatric Hospital.
Nihon Ronen Igakkai Zasshi. 1993 Sep;30(9):778-86. doi: 10.3143/geriatrics.30.778.
In order to evaluate the effect of gender and aging on the diurnal rhythm of blood pressure (BP), we performed ambulatory BP monitoring in 267 normotensive volunteers (mean age +/- SD 52.1 +/- 24.6 years, range 16-93 years, 114 men, 153 women). Ambulatory 24-hour BP was recorded every 30 minutes with an oscillometric method by ABPM630 (Nippon-Kolin, Japan). Circadian rhythm was determined by fitting the 24-hour cosine function curve. Subjects were divided into three age groups, consisting of the Y group (age < 30), M group (age > or = 30 but < 60), and E group (age > or = 60). Highest normal values of the 24-hour mean BP (90 percentile of the values) were 126/75 mmHg in the Y group, 126/76 mmHg in the M group, and 154/85 mmHg in the E group in men. They were 117/67 mmHg, 125/77 mmHg 151/79 mmHg respectively in women. The MESOR of SBP increased with age in women, though it was significantly higher only in the E group among men. The amplitude of SBP decreased with age significantly only in men. The acrophase of SBP shifted to an earlier time of day with aging in both men and women. The trends in the circadian rhythm of DBP with age were similar to those of SBP. In conclusion, the circadian rhythm of blood pressure varies with gender and aging. The 24-hour blood pressure values should be considered with evaluating sex-age matched reference values.
为了评估性别和衰老对血压（BP）昼夜节律的影响，我们对267名血压正常的志愿者进行了动态血压监测（平均年龄±标准差52.1±24.6岁，年龄范围16 - 93岁，男性114名，女性153名）。使用ABPM630（日本尼普洛）通过示波法每30分钟记录一次24小时动态血压。通过拟合24小时余弦函数曲线来确定昼夜节律。受试者被分为三个年龄组，即Y组（年龄<30岁）、M组（年龄≥30岁但<60岁）和E组（年龄≥60岁）。男性中，Y组24小时平均血压的最高正常值（值的第90百分位数）为126/75 mmHg，M组为126/76 mmHg，E组为154/85 mmHg。女性分别为117/67 mmHg、125/77 mmHg和151/79 mmHg。女性收缩压的MESOR随年龄增加，尽管男性仅在E组中显著更高。收缩压的振幅仅在男性中随年龄显著降低。收缩压的峰值相位在男性和女性中都随着衰老而提前。舒张压昼夜节律随年龄的变化趋势与收缩压相似。总之，血压的昼夜节律随性别和衰老而变化。在评估性别 - 年龄匹配的参考值时应考虑24小时血压值。
