A Japanese family with Grayson-Wilbrandt variant of Reis-Bücklers' corneal dystrophy.

A 50-year-old man (the proband) experienced recurring attacks of ocular irritation and had had bilateral ring-shaped anterior corneal opacity since adolescence. Corneal sensation was normal. The proband's 15-year-old daughter also had recurring episodes of ocular irritation and bilateral fleck-like anterior corneal opacities. The proband's deceased father and brother reportedly had similar corneal lesions from adolescence. We believe that the corneal findings in this family may be similar to those found in patients with the Grayson-Wilbrandt variant of Reis-Bücklers' corneal dystrophy.