Tao Y, Yoshii C, Nikaido Y, Tsuda T, Nagata N, Kido M
Division of Respiratory Disease, University of Occupational and Environmental Health, Kitakyushu, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Aug;31(8):983-9.
We report three cases of pulmonary cryptococcosis in which one community acquired and two nosocomial infections were suspected. Clinical studies were focused on histological and immunological diagnosis and antifungal chemotherapy. The first case was initially suspected of having primary cryptococcosis. The second case was first suspected to have BOOP on the basis of clinical and radiological findings. The third was initially suspected of having lung cancer because of an enlarging mass lesion in fibrotic lung and elevated tumor markers. All cases were treated with antifungal agents. Two cases were treated with fluconazole alone, the other case with fluconazole and 5-fluorocytosine. In all cases, the abnormal shadows on chest X-ray demonstrated 50 to 90 percent improvement within 6 months, and cryptococcal antigen in the serum decreased. There were no side effects from the drugs.
我们报告了3例肺隐球菌病病例，其中1例怀疑为社区获得性感染，2例怀疑为医院感染。临床研究主要集中在组织学和免疫学诊断以及抗真菌化疗方面。首例病例最初怀疑患有原发性隐球菌病。第二例病例基于临床和影像学表现最初怀疑患有闭塞性细支气管炎伴机化性肺炎（BOOP）。第三例病例最初因纤维化肺中肿块病变增大及肿瘤标志物升高而怀疑患有肺癌。所有病例均接受了抗真菌药物治疗。2例仅接受氟康唑治疗，另1例接受氟康唑和5-氟胞嘧啶治疗。所有病例中，胸部X线异常阴影在6个月内均有50%至90%的改善，血清中隐球菌抗原减少。未出现药物副作用。
