Kodama H, Yoshida I, Iijima T, Ishikawa S, Ohtaki A, Ohtani Y, Ichikawa H, Takahashi T, Aizaki M, Morishita Y
Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
Kyobu Geka. 1993 Nov;46(12):1017-20.
The effect of extended thymectomy in myasthenia gravis of pure ocular type was investigated in 13 patients, who were divided into the surgical group of nine and the conservative group of four. In the surgical group, the onset was at 47 +/- 20 years old. The preoperative duration of symptoms was 4 +/- 6 years. The age at the time of operation was 51 +/- 16 years old. Three patients had thymomas, including one malignant thymoma. Acetylcholine receptor antibody titer was over normal range with 34.0 +/- 49.7 nmol/l. No postoperative crisis occurred. The palliation rate of the surgical group was more higher through the whole period than that of the conservative group, and increased with progress of the course. The remission occurred in the surgical group, but did not in the conservative group. It took 7 months to improve the symptom in the surgical group, while 18 months in the conservative group. We conclude extended thymectomy is reasonable for patients with myasthenia gravis of pure ocular type.
对13例单纯眼肌型重症肌无力患者进行了扩大胸腺切除术的疗效研究，将其分为手术组9例和保守组4例。手术组发病年龄为47±20岁，术前症状持续时间为4±6年，手术年龄为51±16岁。3例患者有胸腺瘤，其中1例为恶性胸腺瘤。乙酰胆碱受体抗体滴度高于正常范围，为34.0±49.7nmol/l。术后未发生危象。手术组在整个病程中的缓解率均高于保守组，且随病程进展而升高。手术组出现缓解，而保守组未出现缓解。手术组症状改善用时7个月，保守组用时18个月。我们得出结论，扩大胸腺切除术对单纯眼肌型重症肌无力患者是合理的。
