Kozłowski D, Karpowicz A
SKN przy Zakładzie Anatomii Topograficznej Akademii Medycznej, Gdańsku.
Kardiol Pol. 1993 Mar;38(3):181-4.
The material consists of 50 human hearts without either pathological changes or congenital malformations. Macroscopic and microscopic methods were applied. Histological specimens were stained alternatively with hematoxylin-eosin and according to van Giesson and Masson. In each heart the tendon of Todaro was dissected from its portion situated between the inferior vena cava and coronary sinus up to central part of the membranous septum (Fig. 1). The hearts were divided into 3 groups according to age: fetuses (20 hearts), infants (15) and adults (15) (Table I). In all hearts of fetuses and infants the tendon of Todaro was found to be a well-developed cylindrical structure covered with endocardium. In histologic specimens the tendon was s solid structure well-separated from other tissues (Fig. 3, Fig. 4). In hearts of adults (17-45 years old) the tendon of Todaro was less evident. However, in histological specimens it was present as a compact connective tissue band (Fig. 2). In hearts of subjects older than 50, the endocardium of this area was not elevated and not distinguishable even by palpation. The connective tissue band was formed by rather dissipated fibres, poorly separated from surrounding structures. As a result of our study one may conclude that the tendon of Todaro is present in each human heart. It is well-developed in hearts of fetuses and infants. Later it diminishes gradually becoming almost inconspicuous in old subjects.
该材料由50颗无病理变化或先天性畸形的人类心脏组成。采用了宏观和微观方法。组织学标本交替用苏木精-伊红染色，并根据范吉森法和马森法染色。在每颗心脏中，从位于下腔静脉和冠状窦之间的部分直至膜性间隔的中央部分，解剖托达罗腱（图1）。根据年龄将心脏分为3组：胎儿（20颗心脏）、婴儿（15颗）和成年人（15颗）（表I）。在所有胎儿和婴儿的心脏中，托达罗腱被发现是一个发育良好的圆柱形结构，覆盖有内皮。在组织学标本中，该腱是一个与其他组织明显分隔的坚实结构（图3、图4）。在成年人（17 - 45岁）的心脏中，托达罗腱不太明显。然而，在组织学标本中它表现为一条致密的结缔组织带（图2）。在50岁以上受试者的心脏中，该区域的内皮没有隆起，甚至通过触诊也无法区分。结缔组织带由相当分散的纤维形成，与周围结构分隔不佳。我们的研究结果可以得出结论，托达罗腱存在于每颗人类心脏中。它在胎儿和婴儿的心脏中发育良好。后来它逐渐变小，在老年受试者中几乎变得不明显。
