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2
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Phagocytosis and intracellular killing of mucoid and nonmucoid Pseudomonas aeruginosa strains isolated from wounds of burned patients.从烧伤患者伤口分离的黏液型和非黏液型铜绿假单胞菌菌株的吞噬作用及细胞内杀伤
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Macrophage mediated suppression of granulocyte and macrophage growth after burn wound infection reversal by means of anti-PGE2.巨噬细胞介导的烧伤创面感染逆转后粒细胞和巨噬细胞生长抑制作用通过抗前列腺素E2实现。
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Formation of Pseudomonas aeruginosa Biofilms in Full-thickness Scald Burn Wounds in Rats.铜绿假单胞菌在大鼠全层烫伤创面生物膜的形成。
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引用本文的文献

1
Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant Staphylococcus aureus.白细胞介素-18 治疗增强中性粒细胞功能可保护烧伤感染耐甲氧西林金黄色葡萄球菌的小鼠。
Infect Immun. 2011 Jul;79(7):2670-80. doi: 10.1128/IAI.01298-10. Epub 2011 May 2.
2
Macrophage dysfunction after burn injury.烧伤后巨噬细胞功能障碍。
Infect Immun. 1979 Oct;26(1):157-62. doi: 10.1128/iai.26.1.157-162.1979.

本文引用的文献

1
THE ROLE OF THE PHAGOCYTE IN HOST-PARASITE INTERACTIONS. I. THE PHAGOCYTIC CAPABILITIES OF LEUKOCYTES FROM LYMPHOPROLIFERATIVE DISORDERS.吞噬细胞在宿主-寄生虫相互作用中的作用。I. 淋巴增生性疾病中白细胞的吞噬能力。
Cancer Res. 1964 Dec;24:1958-68.
2
CHANGES IN THE HUMAN COMPLEMENT SYSTEM FOLLOWING BURN TRAUMA.烧伤创伤后人体补体系统的变化
Acta Pathol Microbiol Scand. 1963;59:257-70. doi: 10.1111/j.1699-0463.1963.tb01796.x.
3
Phagocytin: a bactericidal substance from polymorphonuclear leucocytes.噬菌素：一种来自多形核白细胞的杀菌物质。
J Exp Med. 1956 May 1;103(5):589-611. doi: 10.1084/jem.103.5.589.
4
Serum and leukocyte lysosomal enzymes. Derangements following severe thermal injury.血清和白细胞溶酶体酶。严重热损伤后的紊乱情况。
Arch Surg. 1967 Sep;95(3):482-91. doi: 10.1001/archsurg.1967.01330150158020.
5
In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.人多形核白细胞的体外杀菌能力：儿童慢性肉芽肿病中活性降低。
J Clin Invest. 1967 Apr;46(4):668-79. doi: 10.1172/JCI105568.
6
Alterations of the immune response following severe thermal injury.严重热损伤后免疫反应的改变。
Arch Surg. 1966 Jul;93(1):75-83. doi: 10.1001/archsurg.1966.01330010077011.
7
A standard animal burn.标准的动物烧伤。
J Trauma. 1968 Nov;8(6):1049-51. doi: 10.1097/00005373-196811000-00006.
8
The phytohemagglutinin (PHA) response in the thermally injured rat.热损伤大鼠的植物血凝素（PHA）反应
Int Arch Allergy Appl Immunol. 1971;40(4-5):707-18. doi: 10.1159/000230453.
9
Neutrophil dysfunction and sepsis in burn injury.烧伤中的中性粒细胞功能障碍与脓毒症
Surg Gynecol Obstet. 1970 Mar;130(3):431-8.
10
Complement-dependent platelet and polymorphonuclear leukocyte reactions.补体依赖性血小板和多形核白细胞反应。
Transplant Proc. 1974 Mar;6(1):27-31.

粒细胞功能与铜绿假单胞菌烧伤创面感染

Granulocyte function and Pseudomonas burn wound infection.

作者信息

McEuen D D, Gerber G C, Blair P, Eurenius K

出版信息

Infect Immun. 1976 Aug;14(2):399-402. doi: 10.1128/iai.14.2.399-402.1976.

DOI:10.1128/iai.14.2.399-402.1976
PMID:823111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC420897/
Abstract

Granulocyte function in burn injury has been evaluated with an in vitro animal assay. Bactericidal activity, using this technique, was markedly depressed only when granulocytes from scald burned rats were challenged with each of three strains of Pseudomonas aeruginosa in the presence of autologous postburn serum or heat-inactivated serum. Preincubation of postburn and normal serum at 37 degrees C for 1 h resulted in normal phagocytosis. These studies validate an investigation of plasma and/or granulocyte replacement therapy in the burned patient.

摘要

通过体外动物试验对烧伤患者的粒细胞功能进行了评估。采用该技术，只有当烫伤大鼠的粒细胞在自体烧伤后血清或热灭活血清存在的情况下，受到三种铜绿假单胞菌菌株中每一种的攻击时，杀菌活性才会显著降低。将烧伤后血清和正常血清在37℃预孵育1小时可使吞噬作用正常。这些研究证实了对烧伤患者进行血浆和/或粒细胞替代治疗的研究。