粒细胞功能与铜绿假单胞菌烧伤创面感染
Granulocyte function and Pseudomonas burn wound infection.
作者信息
McEuen D D, Gerber G C, Blair P, Eurenius K
出版信息
Infect Immun. 1976 Aug;14(2):399-402. doi: 10.1128/iai.14.2.399-402.1976.
Abstract
Granulocyte function in burn injury has been evaluated with an in vitro animal assay. Bactericidal activity, using this technique, was markedly depressed only when granulocytes from scald burned rats were challenged with each of three strains of Pseudomonas aeruginosa in the presence of autologous postburn serum or heat-inactivated serum. Preincubation of postburn and normal serum at 37 degrees C for 1 h resulted in normal phagocytosis. These studies validate an investigation of plasma and/or granulocyte replacement therapy in the burned patient.
摘要
通过体外动物试验对烧伤患者的粒细胞功能进行了评估。采用该技术，只有当烫伤大鼠的粒细胞在自体烧伤后血清或热灭活血清存在的情况下，受到三种铜绿假单胞菌菌株中每一种的攻击时，杀菌活性才会显著降低。将烧伤后血清和正常血清在37℃预孵育1小时可使吞噬作用正常。这些研究证实了对烧伤患者进行血浆和/或粒细胞替代治疗的研究。
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