Richardus J H, Smith T C
McKean Rehabilitation Centre, Thailand.
Lepr Rev. 1993 Sep;64(3):270-4. doi: 10.5935/0305-7518.19930031.
The objective of this case-control study was to identify factors associated with the development of squamous cell carcinoma (SCC) in plantar ulcers of leprosy patients. We examined 2 matched groups consisting of leprosy patients with and without SCC in a plantar ulcer. No correlations were found between the development of SCC and race, profession, place of origin, duration of leprosy, the type and duration of leprosy chemotherapy, presence of bone involvement and type of ulcer care treatment given. The only statistically valid finding was that the duration of the ulcer was significantly lower in the group with malignant change. In this group there was an apparently higher use of pesticides, the difference being not of statistical significance. It is concluded that factors other than ulcer duration need to be looked for, in order to identify factors influencing malignant change in plantar ulcers of leprosy patients.
这项病例对照研究的目的是确定与麻风病患者足底溃疡发生鳞状细胞癌（SCC）相关的因素。我们检查了2组匹配的人群，一组是足底溃疡处发生SCC的麻风病患者，另一组是未发生SCC的麻风病患者。SCC的发生与种族、职业、出生地、麻风病病程、麻风病化疗的类型和疗程、是否存在骨受累以及所给予的溃疡护理治疗类型之间均未发现相关性。唯一具有统计学意义的发现是，发生恶变的组中溃疡持续时间明显更短。在该组中，农药的使用明显更多，差异无统计学意义。得出的结论是，为了确定影响麻风病患者足底溃疡恶变的因素，需要寻找溃疡持续时间以外的其他因素。
