Bobhate S K, Madankar S T, Parate S N, Choudhary R K, Kumbhalkar D T
Faculty of Medicine, Nagpur University.
Indian J Lepr. 1993 Jul-Sep;65(3):297-303.
Malignant transformation of plantar ulcers in leprosy is not uncommon. The apparent rarity of these neoplasms could be because many observed cases are not reported. To determine the extent of the problem, 133 consecutive cases of plantar ulcers seen over two years were studied clinically as well as histologically. Plantar ulcers were more common in the distal third of foot (64.67%) but malignant transformation was seen more often in plantar ulcers of proximal third of foot (64.29%). Malignant transformation was more common in plantar ulcers of long duration. Histologically, most of the lesions were benign, being instances of pseudo-epitheliomatous hyperplasia (57.89%) or atypical pseudo-epitheliomatous hyperplasia (13.53%). However, squamous cell carcinoma was observed in 10.53% cases. Thus it may be that more cases with this complication will be detected if it is borne in mind that malignant change may be encountered in such ulcers.
麻风足底溃疡的恶性转化并不罕见。这些肿瘤明显罕见可能是因为许多观察到的病例未被报告。为了确定问题的严重程度，对连续两年内见到的133例足底溃疡病例进行了临床和组织学研究。足底溃疡在足部远端三分之一处更为常见（64.67%），但恶性转化在足部近端三分之一处的足底溃疡中更常出现（64.29%）。恶性转化在病程较长的足底溃疡中更为常见。组织学上，大多数病变是良性的，为假上皮瘤样增生（57.89%）或非典型假上皮瘤样增生（13.53%）的病例。然而，在10.53%的病例中观察到了鳞状细胞癌。因此，如果记住在这类溃疡中可能会遇到恶性变化，可能会发现更多有这种并发症的病例。
