低代谢状态正常化对自发性高血压大鼠和原发性高血压患者血压的影响。

Effect of normalization of hypometabolic state on blood pressure in spontaneously hypertensive rats and in patients with essential hypertension.

作者信息

Koizumi Y, Aizawa T, Tawata M, Yamada T, Yamori Y

出版信息

J Am Geriatr Soc. 1976 Oct;24(10):454-7. doi: 10.1111/j.1532-5415.1976.tb03259.x.

DOI:10.1111/j.1532-5415.1976.tb03259.x

Abstract

Spontaneously hypertensive rats (SHR) manifest a hypothyroid state as evidenced by increased thyroid weight, an increased level of plasma thyroid-stimulating hormone (TSH) and a decreased level of plasma thyroxine (T4) and triiodothyronine (T3). In 18 patients with essential hypertension, plasma TSH, T4 and T3 concentrations were all within the normal range, but the T4 level was significantly lower than in the controls. Among 21 hypothyroid patients, 2 had essential hypertension. Administration of thyroid hormone brought the metabolic state to normal in SHR and in hypothyroid patients but failed to affect the blood pressure. It is suggested that abnormality of thyroid function is neither the cause nor the accentuating factor in the development of hypertension in SH rats and in man.

摘要

自发性高血压大鼠（SHR）表现出甲状腺功能减退状态，这可通过甲状腺重量增加、血浆促甲状腺激素（TSH）水平升高以及血浆甲状腺素（T4）和三碘甲状腺原氨酸（T3）水平降低得到证明。在18例原发性高血压患者中，血浆TSH、T4和T3浓度均在正常范围内，但T4水平明显低于对照组。在21例甲状腺功能减退患者中，有2例患有原发性高血压。给予甲状腺激素可使SHR和甲状腺功能减退患者的代谢状态恢复正常，但未能影响血压。提示甲状腺功能异常既不是SH大鼠和人类高血压发生的原因，也不是加重因素。