Kihara M, Zollman P J, Schmelzer J D, Low P A
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905.
Muscle Nerve. 1993 Dec;16(12):1383-9. doi: 10.1002/mus.880161218.
Microsphere embolization of peripheral nerve results in a variable degree of ischemic fiber degeneration. To enhance the utility of the model, we evaluated the relationship between dose of microspheres to the supplying arteries of the sciatic-tibial nerve to nerve blood flow (NBF), electrophysiology, morphology, and behavioral changes. There was considerable variability in the effect of embolization on nerve pathology in individual nerves. However, the dose of microspheres regressed with the degree of hindlimb paresis, reduction in NBF, degree of fiber pathology, and ischemic conduction failure of the tibial nerve, evaluated at day 7. All nerves with severe (grade 4) fiber degeneration had flows of < 3 mL x 100 g-1 x min-1. We conclude that it is possible to predict with a high degree of accuracy the severity of fiber degeneration by the degree of NBF reduction and by the electrophysiologic abnormalities.
外周神经微球栓塞会导致不同程度的缺血性纤维变性。为提高该模型的实用性，我们评估了坐骨 - 胫神经供血动脉的微球剂量与神经血流（NBF）、电生理学、形态学及行为变化之间的关系。栓塞对各条神经病理的影响存在相当大的变异性。然而，在第7天评估时，微球剂量与后肢麻痹程度、NBF降低程度、纤维病理程度以及胫神经的缺血性传导衰竭呈负相关。所有出现严重（4级）纤维变性的神经血流均<3 mL×100 g⁻¹×min⁻¹。我们得出结论，通过NBF降低程度和电生理异常情况可以高度准确地预测纤维变性的严重程度。
