König F, Stumpp W, Kohler T, Hole G, Fuchs G
Psychiatrisches Landeskrankenhaus Weissenau, Abteilung Psychiatrie I der Universität, Ulm.
Nervenarzt. 1993 Oct;64(10):681-4.
The influence of neuroleptic drugs on body temperature regulation is well established. Even with atypical neuroleptic drugs such as clozapine, hyperthermia has been observed as well as the malignant neuroleptic syndrome. It is likely that the influence of clozapine affects the immune response. A case is reported in which afebrile angina tonsillaris and endocarditis developed, as a result of high-dosage therapy with clozapine over several years. Besides the special features of the course, differential diagnosis, therapy and possible influence on the body temperature and the immune response are discussed.
抗精神病药物对体温调节的影响已得到充分证实。即使使用氯氮平这类非典型抗精神病药物，也观察到了体温过高以及恶性抗精神病综合征。氯氮平的影响可能会作用于免疫反应。本文报告了一例病例，患者因多年高剂量服用氯氮平而出现无热型扁桃体炎和心内膜炎。除了病程的特殊特征外，还讨论了鉴别诊断、治疗以及对体温和免疫反应可能产生的影响。
