Naruszewicz-Lesiuk D, Kulczycki J, Iwińska-Buksowicz B, Wieczorkiewicz M, Gut W
Zakładu Epidemiologii Państwowego Zakładu Higieny, Warszawie.
Neurol Neurochir Pol. 1993 May-Jun;27(3):341-8.
The authors present the results of an epidemiological study of SSPE in Poland conducted since 15 years. Since the years covered by the study (1977-1991) included the first period after the introduction of obligatory vaccinations against measles in our country, the most important aim of this analysis was to find out the possible influence of the effect of these vaccinations on SSPE incidence. A comparison of the data obtained in successive stages of the study shows that a slow gradual decrease of the annual incidence of SSPE has been taking place in our country (from at least 1.6 per million before 1983 to 0.69 in 1991). The effect of the vaccinations is visible also in a significant increase of the mean age of SSPE onset which is a result of ever more widespread vaccination of the youngest children. These observations indicate unequivocally that the aetiological factor in SSPE is a wild strain of measles virus and not that used for vaccinations.
作者展示了自15年前起在波兰开展的亚急性硬化性全脑炎（SSPE）流行病学研究结果。由于该研究涵盖的年份（1977年至1991年）包括我国引入强制性麻疹疫苗接种后的首个时期，此分析的最重要目的是查明这些疫苗接种效果对SSPE发病率的可能影响。研究连续阶段所获数据的比较表明，我国SSPE的年发病率一直在缓慢逐渐下降（从1983年前至少每百万1.6例降至1991年的0.69例）。疫苗接种的效果还体现在SSPE发病平均年龄显著增加，这是最年幼儿童疫苗接种日益普及的结果。这些观察结果明确表明，SSPE的病因是麻疹病毒野毒株，而非用于疫苗接种的毒株。
