Emrich H M, Dose M, Wolf R
Department of Clinical Psychiatry, Medizinische Hochschule Hannover, FRG.
Neuropsychobiology. 1993;27(3):158-62. doi: 10.1159/000118973.
One of the main challenges in the psychopharmacology of affective disorders is to explain the partial similarity of the profiles of action of the different mood-stabilizers lithium, carbamazepine, and valproate, and possibly also calcium antagonists like verapamil and nimodipine. Elucidation of this problem requires understanding the basic neurobiological mechanisms underlying the pathogenesis of affective disorders and would also imply elucidating the modes of action of the different compounds. However, we are far from reaching such an understanding.
情感障碍精神药理学的主要挑战之一是解释不同心境稳定剂（锂盐、卡马西平和丙戊酸盐）以及可能还有维拉帕米和尼莫地平这类钙拮抗剂的作用谱的部分相似性。阐明这个问题需要理解情感障碍发病机制背后的基本神经生物学机制，也意味着要阐明不同化合物的作用方式。然而，我们远未达到这样的理解。
