Weiss G K, Castillo N, Fernandez M
University of New Mexico School of Medicine, Department of Physiology, Albuquerque 87131.
Neurosci Lett. 1993 Jul 9;157(1):91-4. doi: 10.1016/0304-3940(93)90650-a.
Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. These observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (HPA) axis, particularly the glucocorticoids, play a role in epileptogenesis.
费希尔大鼠和刘易斯大鼠分别在早晨和晚上进行杏仁核点燃。费希尔大鼠在点燃至第2阶段的速率上表现出昼夜变化，而刘易斯大鼠则不存在这种变化。刘易斯大鼠在点燃至第2阶段的时间也长得多，皮下植入皮质酮丸可加快这一速率。这些观察结果与下丘脑-垂体-肾上腺（HPA）轴的激素，特别是糖皮质激素在癫痫发生中起作用的假说一致。
