Weiss G, Lucero K, Fernandez M, Karnaze D, Castillo N
University of New Mexico, School of Medicine, Department of Physiology, Albuquerque 87131.
Brain Res. 1993 May 28;612(1-2):354-6. doi: 10.1016/0006-8993(93)91686-m.
The hypothalamic-pituitary adrenal axis (HPAA) is activated during kindled seizures and the circadian changes in this axis may contribute to the circadian variation in the kindling rate. Changes in the rate of seizure development were examined in rats that were amygdala kindled in the a.m., at midday and in the p.m.. Sham operated control groups were compared to adrenalectomized groups. Adrenalectomy had no effect on the midday rate but abolished the normal circadian variation by accelerating the rate in the a.m. and decreasing the rate in the p.m.. These results suggest a complicated relationship of kindled seizure rate to the hormones of the HPAA axis.
下丘脑-垂体-肾上腺轴（HPAA）在点燃性癫痫发作期间被激活，该轴的昼夜节律变化可能导致点燃率的昼夜节律变化。研究了在上午、中午和下午进行杏仁核点燃的大鼠癫痫发作发展速率的变化。将假手术对照组与肾上腺切除组进行比较。肾上腺切除术对中午的速率没有影响，但通过加快上午的速率和降低下午的速率消除了正常的昼夜节律变化。这些结果表明点燃性癫痫发作速率与HPAA轴激素之间存在复杂的关系。
