丙戊茶碱（HWA285）可抑制短暂性脑缺血期间大鼠纹状体中多巴胺的释放，并调节其代谢。

Propentofylline (HWA285) inhibits the release of dopamine during transient ischemia and modulates its metabolism in rat striatum.

作者信息

Shimizu K, Ogino M, Yamaguchi N, Mitani S, Saito R, Kawase T, Toya S

机构信息

Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan.

出版信息

Neurosci Lett. 1993 Aug 6;158(1):9-12. doi: 10.1016/0304-3940(93)90599-g.

DOI:10.1016/0304-3940(93)90599-g

PMID:8233079

Abstract

Propentofylline (HWA285) has been reported to protect neuronal cells through the inhibition of glutamate release during transient ischemia. We studied whether HWA285 inhibits dopamine (DA) release, and how HWA285 modulates DA metabolism in the rat model. HWA285 was perfused through a microdialysis probe placed in the rat striatum during 20 min transient ischemia. In rats perfused by HWA285, ischemic DA release was significantly inhibited, and DA metabolism showed better recovery in contrast with unperfused rats.

摘要

据报道，丙戊茶碱（HWA285）可通过抑制短暂性脑缺血期间的谷氨酸释放来保护神经元细胞。我们研究了HWA285是否抑制多巴胺（DA）释放，以及HWA285如何调节大鼠模型中的DA代谢。在20分钟的短暂性脑缺血期间，通过置于大鼠纹状体的微透析探针灌注HWA285。在灌注HWA285的大鼠中，缺血性DA释放受到显著抑制，与未灌注的大鼠相比，DA代谢显示出更好的恢复。