Hochstenbach S L, Solano-Flores L P, Ciriello J
Department of Physiology, University of Western Ontario, London, Canada.
Neurosci Lett. 1993 Aug 20;158(2):225-8. doi: 10.1016/0304-3940(93)90270-u.
Experiments were done in conscious rats to investigate the effect of intravenous infusion of hypertonic saline on the induction of the protein Fos, in brainstem neurons. Neurons containing Fos-like immunoreactivity were observed in the caudal nucleus of the solitary tract (NTS), the caudal and rostral ventrolateral medulla, and parabrachial nucleus after an infusion of solutions containing 1.4 M NaCl. Little or no expression of Fos was detected in brainstem neurons after intravenous infusions of either physiological (143 mM) or hypotonic (106 mM) NaCl solutions. These data provide evidence for the involvement of brainstem structures in osmoregulatory functions and suggest that brainstem neuronal circuits that function in cardiovascular regulation may also be shared by those involved in body fluid homeostasis.
在清醒大鼠身上进行实验，以研究静脉输注高渗盐水对脑干神经元中蛋白Fos诱导的影响。在输注含1.4 M NaCl的溶液后，在孤束尾核（NTS）、延髓尾侧和头端腹外侧以及臂旁核中观察到含有Fos样免疫反应性的神经元。静脉输注生理浓度（143 mM）或低渗（106 mM）NaCl溶液后，在脑干神经元中几乎未检测到Fos表达。这些数据为脑干结构参与渗透压调节功能提供了证据，并表明参与心血管调节的脑干神经回路可能也参与了体液稳态调节。
