Yamashita H, Zhang Y X, Nakamura S
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Neurosci Lett. 1993 Aug 20;158(2):229-31. doi: 10.1016/0304-3940(93)90271-l.
The effect of thiamin and its phosphate esters on dopamine (DA) release was examined in the rat striatum using an in vivo microdialysis. Intrastriatal administration of thiamin triphosphate (TTP) or thiamin diphosphate (TDP) induced DA release, but thiamin monophosphate (TMP) or thiamin did not show any change. In the absence of Ca2+ in the perfusate, TTP did not increase the DA release. omega-Conotoxin did not decrease the TTP-dependent DA release. These findings suggest that, in contrast to TMP and thiamin, TTP and TDP may play a specific role in DA release from nerve terminals.
利用体内微透析技术，在大鼠纹状体中研究了硫胺素及其磷酸酯对多巴胺（DA）释放的影响。纹状体内注射三磷酸硫胺素（TTP）或二磷酸硫胺素（TDP）可诱导DA释放，但一磷酸硫胺素（TMP）或硫胺素未显示出任何变化。在灌注液中无Ca2+的情况下，TTP不会增加DA释放。ω-芋螺毒素不会降低TTP依赖性DA释放。这些发现表明，与TMP和硫胺素不同，TTP和TDP可能在神经末梢DA释放中起特定作用。
