Alizadeh Mohammad, Kheirouri Sorayya, Keramati Majid
Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.
Brain Sci. 2023 Jul 24;13(7):1119. doi: 10.3390/brainsci13071119.
Dietary constituents may affect the progression of Parkinson's disease (PD). This study aimed to assess the contribution of dietary intake of vitamins and minerals to the severity, motor and non-motor symptoms, and risk of PD.
In this case-control study, 120 patients with PD and 50 healthy participants participated. Dietary intake of vitamins and minerals was determined using a 147-item food frequency questionnaire. The severity of PD was determined by the Unified Parkinson's Disease Rating Scale (UPDRS).
Patients with PD had lower intake of several vitamins and minerals including lycopene, thiamine, vitamin B6, vitamin B12, pantothenic acid, magnesium, zinc, manganese, selenium, chromium, and phosphorus, but had higher intake of α-tocopherol. High dietary intake of vitamin A, α-carotene, β-cryptoxanthin, vitamin C, and α-tocopherol were correlated with increased odds of PD. High intake of lycopene, thiamin, vitamin B6, pantothenic acid, magnesium, zinc, manganese, chromium, and phosphorous correlated with reduced odds of PD. The predictive power of α-tocopherol concerning the risk of PD was stronger relative to other vitamins. Dietary intake of pantothenic acid was negatively correlated with PD severity and symptoms of motor examination and complication. The severity and motor symptoms of PD were also negatively correlated with β-carotene, vitamin C, riboflavin, vitamin B6, and biotin intake. The UPDRS total score and motor symptoms in PD patients were negatively correlated with phosphorus, magnesium, zinc, manganese, and chromium, and strongly with potassium intake.
The findings indicate that adequate dietary intake of vitamins and minerals may have a preventive effect on developing PD and progression of motor decline.
饮食成分可能会影响帕金森病（PD）的进展。本研究旨在评估维生素和矿物质的饮食摄入量对PD严重程度、运动和非运动症状以及患病风险的影响。
在这项病例对照研究中，120例PD患者和50名健康参与者参与其中。使用一份包含147个条目的食物频率问卷来确定维生素和矿物质的饮食摄入量。通过统一帕金森病评定量表（UPDRS）来确定PD的严重程度。
PD患者几种维生素和矿物质的摄入量较低，包括番茄红素、硫胺素、维生素B6、维生素B12、泛酸、镁、锌、锰、硒、铬和磷，但α-生育酚的摄入量较高。高饮食摄入维生素A、α-胡萝卜素、β-隐黄质、维生素C和α-生育酚与PD患病几率增加相关。高摄入番茄红素、硫胺素、维生素B6、泛酸、镁、锌、锰、铬和磷与PD患病几率降低相关。相对于其他维生素，α-生育酚对PD风险的预测能力更强。泛酸的饮食摄入量与PD严重程度、运动检查症状和并发症呈负相关。PD的严重程度和运动症状也与β-胡萝卜素、维生素C、核黄素、维生素B6和生物素的摄入量呈负相关。PD患者UPDRS总分和运动症状与磷、镁、锌、锰和铬呈负相关，与钾摄入量呈强负相关。
研究结果表明，充足的维生素和矿物质饮食摄入可能对PD的发生和运动功能衰退的进展具有预防作用。
