Otsuka M, Ichiya Y, Kuwabara Y, Fukumura T, Sasaki M, Masuda K
Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nucl Med Commun. 1993 Oct;14(10):862-7. doi: 10.1097/00006231-199310000-00005.
The striatal to cerebellar (S/C) activity ratio for estimating nigrostriatal function was compared with the Patlak analyses in 18F-dopa (FD) positron emission tomography (PET) with pretreatment with 100 mg carbidopa (CD). Two different time-activity curves of plasma FD or cerebellar 18F were used for the Patlak analyses. The S/C ratio increased linearly with time for 120 min and the ratio at 120 min correlated closely with the uptake constants by the two Patlak analyses (r = 0.94, 0.96) in six normal volunteers and six parkinsonism patients. The S/C ratio and the uptake constant by the cerebellar Patlak analysis without CD also showed a fairly good correlation (n = 30, r = 0.85). Then, the S/C ratios with and without CD were compared. Since CD increased both the striatal and the cerebellar radioactivities proportionally within each subject, CD did not change the S/C ratios. The S/C ratios both with and without CD were simple and comparable to the uptake constants in the FD PET studies.
在18F - 多巴（FD）正电子发射断层扫描（PET）中，比较了用于评估黑质纹状体功能的纹状体与小脑（S/C）活性比值与Patlak分析，其中在预处理时使用了100mg卡比多巴（CD）。Patlak分析使用了两种不同的血浆FD或小脑18F时间 - 活性曲线。在6名正常志愿者和6名帕金森病患者中，S/C比值在120分钟内随时间呈线性增加，120分钟时的比值与两种Patlak分析的摄取常数密切相关（r = 0.94，0.96）。在未使用CD的情况下，小脑Patlak分析的S/C比值与摄取常数也显示出相当好的相关性（n = 30，r = 0.85）。然后，比较了使用和未使用CD时的S/C比值。由于CD在每个受试者体内按比例增加了纹状体和小脑的放射性，所以CD并未改变S/C比值。使用和未使用CD时的S/C比值都很简单，并且与FD PET研究中的摄取常数具有可比性。
