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对甲状腺毒症门诊患者进行¹³¹I治疗时公众所接受辐射剂量的分析。

Analysis of radiation doses received by the public from 131I treatment of thyrotoxic outpatients.

作者信息

Wasserman H J, Klopper J F

机构信息

Department of Nuclear Medicine, Tygerberg Hospital, Republic of South Africa.

出版信息

Nucl Med Commun. 1993 Sep;14(9):756-60. doi: 10.1097/00006231-199309000-00004.

Abstract

Radiation doses to the family and general public from 131I therapy of outpatients were assessed for comparison with the 1990 International Commission on Radiation Protection (ICRP) dose limits. Doses to family members of such patients, measured by previous workers, were converted to show that on average 5.6 +/- 3.7 microSv MBq-1 is received by the spouse and 1.5 +/- 0.87 microSv MBq-1 by other family members. It was deduced that the average dose to the spouse (D microSv MBq-1) when couples sleep apart for T days after administration is given by: D = 2.528 + 3.072e-0.11T if an effective half-life, T(eff), of 6.35 days is used. The cumulative effect of repeated treatments should be considered and in view of ALARA it is recommended that couples sleep apart for at least 14 days after each administration, even if this is below limits permitted by authorities. The dose to a pregnant colleague or family member other than the wife should be below 2 mSv if the total administered activity is not more than 600 MBq. If the wife is pregnant, couples should sleep apart for at least 30 days after administration.

摘要

评估了门诊患者接受¹³¹I治疗时对其家人和公众的辐射剂量,以便与1990年国际辐射防护委员会(ICRP)的剂量限值进行比较。先前研究人员测量的此类患者家庭成员所受剂量经换算后表明,配偶平均接受的剂量为5.6±3.7微希沃特/兆贝可,其他家庭成员为1.5±0.87微希沃特/兆贝可。据推断,给药后夫妻分居T天,配偶所受平均剂量(D,微希沃特/兆贝可)为:若有效半衰期T(eff)为6.35天,则D = 2.528 + 3.072e⁻⁰·¹¹T。应考虑重复治疗的累积效应,鉴于“尽可能低合理可行”原则(ALARA),建议每次给药后夫妻至少分居14天,即便这低于当局允许的限值。若总给药活度不超过600兆贝可,怀孕的同事或妻子以外的家庭成员所受剂量应低于2毫希沃特。若妻子怀孕,给药后夫妻应至少分居30天。

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