O'Doherty M J, Kettle A G, Eustance C N, Mountford P J, Coakley A J
Department of Nuclear Medicine, Kent and Canterbury Hospital, UK.
Nucl Med Commun. 1993 Mar;14(3):160-8. doi: 10.1097/00006231-199303000-00003.
Recommendations for restricting the exposure to radiation of members of the public coming into contact with thyrotoxic patients treated with 131I are currently based on the activity retained by the patient, and not on the doses likely to be received by such individuals. In order to examine whether these current implications of a reduction in this limit to 1 mSv, measurements were made of the dose rates at distances of 0.1, 0.5 and 1.0 m from 60 patients just before they left the nuclear medicine department. These measurements were repeated 1, 3, 6, 8 and 10 days after administration for 30 patients, and the radioactivity in samples of saliva taken on each of these days and secreted in sweat over the first 24 h were also measured. Doses were estimated for administered activities of approximately 200-600 MBq, assuming appropriate values for the times and distances spent near other individuals while travelling, at work, at home and near to young children considered in three age groups (< 2, 2-5 and 5-11 years). Periods of restriction were derived which would reduce these doses to 5 or 1 mSv. For a dose limit of 5 mSv, there is no need to restrict private travel, public transport journeys can last up to 7 h, a patient can return to work immediately, but sleeping with a partner will have to be restricted even for the minimum activity of 200 MBq.(ABSTRACT TRUNCATED AT 250 WORDS)
目前,关于限制接触接受过¹³¹I治疗的甲状腺毒症患者的公众所受辐射的建议,是基于患者体内留存的活度,而非这些个体可能接受的剂量。为了研究将此限值降至1毫希沃特的当前影响,在60名患者即将离开核医学科之前,测量了距离他们0.1米、0.5米和1.0米处的剂量率。对30名患者在给药后1天、3天、6天、8天和10天重复进行了这些测量,还测量了这些日子采集的唾液样本中的放射性以及头24小时汗液中分泌的放射性。假设在旅行、工作、家中以及接近三个年龄组(<2岁、2 - 5岁和5 - 11岁)的幼儿附近时,与他人相处的时间和距离取适当值,对大约200 - 600兆贝可的给药活度估算了剂量。得出了将这些剂量降至5毫希沃特或1毫希沃特的限制期。对于5毫希沃特的剂量限值,无需限制私人旅行,公共交通旅程最长可达7小时,患者可立即返回工作岗位,但即使对于200兆贝可的最低活度,与伴侣同睡也必须受限。(摘要截选于250字)