Jurin M, Zarković N, Hrzenjak M, Ilić Z
Department of Experimental Biology and Medicine, Ruder Bosković Institute, Zagreb, Croatia.
Oncology. 1993 Nov-Dec;50(6):393-8. doi: 10.1159/000227217.
There are numerous data on the immunostimulative and antitumorous activity of various Viscum album tissue extracts. Isorel (Novipharm, Austria) is one of these compounds. We found that in mice an increased number of plaque-forming cells to sheep red blood cells (SRBC) followed the injection of Isorel together with SRBC. Further, survival time of a foreign skin graft was shortened if Isorel was applied at the correct time. Finally, suppressed immune reactivity in tumorous mice recovered following Isorel injection. Isorel was further shown to be cytotoxic to tumor cells in vitro. Its application to tumor-bearing mice could prolong their life but without any therapeutic effect. However, a combination of local irradiation and Isorel was very effective: following 43 Gy of local irradiation to a transplanted methylcholanthrene-induced fibrosarcoma (volume about 240 mm3) growing in syngeneic CBA/HZgr mice, the tumor disappeared in about 25% of the animals; the addition of Isorel increased the incidence of cured animals to over 65%. The combined action of Isorel, influencing tumor viability on the one hand and the host's immune reactivity on the other, seems to be favorable for its antitumor action in vivo.
关于各种槲寄生组织提取物的免疫刺激和抗肿瘤活性，有大量数据。异瑞（奥地利诺维法姆公司）就是其中一种化合物。我们发现，在小鼠中，将异瑞与绵羊红细胞（SRBC）一起注射后，针对SRBC的噬斑形成细胞数量增加。此外，如果在正确时间应用异瑞，异体皮肤移植的存活时间会缩短。最后，肿瘤小鼠中被抑制的免疫反应性在注射异瑞后恢复。异瑞在体外还被证明对肿瘤细胞具有细胞毒性。将其应用于荷瘤小鼠可延长其寿命，但无任何治疗效果。然而，局部照射与异瑞联合使用非常有效：对同基因CBA/HZgr小鼠体内生长的移植性甲基胆蒽诱导纤维肉瘤（体积约240立方毫米）进行43戈瑞的局部照射后，约25%的动物肿瘤消失；添加异瑞使治愈动物的发生率提高到65%以上。异瑞一方面影响肿瘤活力，另一方面影响宿主免疫反应性，其联合作用似乎有利于其在体内的抗肿瘤作用。
