Rohn G N, Meyerhoff W L, Wright C G
Department of Otorhinolaryngology, University of Texas Southwestern Medical Center, Dallas.
Otolaryngol Clin North Am. 1993 Oct;26(5):747-58.
Topical otic preparations are commonly prescribed by otolaryngologists--head and neck surgeons. It is well documented in the literature that some agents in these preparations are ototoxic when applied to the middle ear in experimental animals, although the occurrence of ototoxicity in the clinical setting is controversial. This article discusses topical otic preparations currently available as well as various other agents. The clinician should prescribe these preparations with close surveillance for potential ototoxicity.
局部耳部制剂通常由耳鼻喉科医生——头颈外科医生开具处方。文献中有充分记载，这些制剂中的一些药物在实验动物中耳给药时具有耳毒性，尽管临床环境中耳毒性的发生存在争议。本文讨论了目前可用的局部耳部制剂以及各种其他药物。临床医生在开具这些制剂时应密切监测潜在的耳毒性。
