Haynes David S, Rutka John, Hawke Michael, Roland Peter S
The Otology Group of Vanderbilt, Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Medical Center East S. Tower 7209, 1215 21st Avenue South, Nashville, TN 37232-5555, USA.
Otolaryngol Clin North Am. 2007 Jun;40(3):669-83, xi. doi: 10.1016/j.otc.2007.03.010.
Various topical preparations are widely used for treating external otitis, acute otitis media with perforation, post-tympanostomy tube otorrhea, and chronic suppurative otitis media. Solutions and suspensions that enter the middle ear through a perforated tympanic membrane can reach the inner ear by crossing through the round window membrane. The safety of various components of otic solutions used in this way, particularly aminoglycosides, corticosteroids, solvents, and preservatives, has been questioned in light of their ototoxic potential. The authors' objective is to review the literature discussing the safety of commonly used classes of otic preparations in settings in which the constituents can access the middle and inner ear in high concentrations and discuss their clinical experience with ototoxicity and experience with medical-legal issues.
各种局部制剂被广泛用于治疗外耳炎、鼓膜穿孔的急性中耳炎、鼓膜置管后耳漏以及慢性化脓性中耳炎。通过穿孔鼓膜进入中耳的溶液和混悬液可穿过圆窗膜到达内耳。鉴于其耳毒性潜力，以这种方式使用的耳用溶液的各种成分，特别是氨基糖苷类、皮质类固醇、溶剂和防腐剂的安全性受到了质疑。作者的目的是回顾文献，讨论常用耳用制剂在其成分可高浓度进入中耳和内耳的情况下的安全性，并讨论他们在耳毒性方面的临床经验以及医疗法律问题方面的经验。
