Bourée P, Duedari N, Bisaro F, Norol F
Département des Maladies Parasitaires et Tropicales, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Pathol Biol (Paris). 1993 Apr;41(4):410-4.
To prevent the side effects as encephalitis, related with diethylcarbamazine treatment in loiasis, an exchange blood transfusion was proposed. To avoid the disadvantage of this heavy technique, the authors are proposing filariopheresis to trap the microfilariae using cytapheresis technique and filtration. They obtained a medium 75 p. cent microfilariae extraction: 55-70 p. cent by cytapheresis and 5-20 p. cent by filtration. The number of blood cells must be supervised as an important decrease of the platelets may occur temporary. This simple and not expensive technique is efficient, but diethylcarbamazine treatment must be instituted very quickly after filariopheresis session. Furthermore, the millions of microfilariae collected can provide useful antigen for immuno-parasitological tests.
为预防在罗阿丝虫病中与乙胺嗪治疗相关的如脑炎等副作用,有人提出进行换血输血。为避免这种复杂技术的缺点,作者们提出采用血细胞分离技术和过滤的方法进行丝虫单采以捕获微丝蚴。他们获得了平均75%的微丝蚴提取率:通过血细胞分离法提取55%-70%,通过过滤法提取5%-20%。必须监测血细胞数量,因为血小板数量可能会暂时出现显著下降。这种简单且成本不高的技术是有效的,但在丝虫单采术后必须尽快开始乙胺嗪治疗。此外,收集到的数百万微丝蚴可为免疫寄生虫学检测提供有用的抗原。