Wołowiec D, Ffrench M
Katedra i Klinika Hematologii i Chorób Rozrostowych Akademii Medycznej, Wrocławiu.
Postepy Hig Med Dosw. 1993;47(3):183-91.
Mitotic cyclins constitute a regulatory subunit of the histone H1 kinase complex. On the ground of their primary structure they are divided into two classes A and B, both necessary for the mitosis. Cyclin A activates histone H1 kinase and becomes destroyed by proteolysis earlier than cyclines B and plays an important role in the DNA replication. Cyclins A and B may be involved in the development of neoplastic disorders either directly (inappropriate expression of the cyclin A gene caused by hepatitis B virus in hepatocellular carcinoma, or interactions of this cyclin with factors participating in the regulation of cell proliferation) or indirectly by phosphorylation of some oncogene or antioncogene proteins by a cdk (cyclin dependent kinase).
有丝分裂周期蛋白构成组蛋白H1激酶复合物的调节亚基。根据其一级结构，它们被分为A和B两类，两者都是有丝分裂所必需的。周期蛋白A激活组蛋白H1激酶，并比周期蛋白B更早地被蛋白水解破坏，在DNA复制中起重要作用。周期蛋白A和B可能直接（如乙型肝炎病毒导致的肝细胞癌中周期蛋白A基因的不适当表达，或该周期蛋白与参与细胞增殖调节的因子相互作用）或间接通过细胞周期蛋白依赖性激酶（cdk）对某些癌基因或抗癌基因蛋白的磷酸化参与肿瘤性疾病的发生发展。
