Wołowiec D
Katedra i Klinika Hematologii i Chorób Rozrostowych AM we Wrocławiu.
Acta Haematol Pol. 1994;25(3):195-203.
Cyclins are proteins which activate a family of serine-threonine kinases called cdk (cyclin-dependent kinases) responsible for progression through the cell cycle. Human cyclins are divided into two groups: mitotic cyclins (cyclins A and B) which regulate cell division, and G1 cyclins (C, D and E) involved in early stages of cell cycle. Cyclins and their cdk partners participate in the pathogenesis of neoplastic proliferation by phosphorylating some oncogenes and antioncogenes, for example the protein encoded by the retinoblastoma susceptibility gene (pRb). Moreover, hyperexpression of one or more classes of cyclins on the gene, mRNA and/or protein level is sometimes observed in neoplastic cells of different origin, for example the rearrangement of the cyclin D1 gene with ectopic expression of its protein product in centrocytic lymphomas with translocation t(11; 14) (q13; q32). Mitotic cyclins can serve as a marker of proliferating cells.
细胞周期蛋白是一类蛋白质，它们可激活名为细胞周期蛋白依赖性激酶（cdk）的丝氨酸 - 苏氨酸激酶家族，该家族负责调控细胞周期进程。人类细胞周期蛋白分为两组：调控细胞分裂的有丝分裂细胞周期蛋白（细胞周期蛋白A和B），以及参与细胞周期早期阶段的G1期细胞周期蛋白（细胞周期蛋白C、D和E）。细胞周期蛋白及其cdk伴侣通过磷酸化某些癌基因和抗癌基因，例如视网膜母细胞瘤易感基因（pRb）编码的蛋白质，参与肿瘤增殖的发病机制。此外，有时在不同来源的肿瘤细胞中可观察到一类或多类细胞周期蛋白在基因、mRNA和/或蛋白质水平上的过度表达，例如在伴有t(11; 14) (q13; q32)易位的中心细胞淋巴瘤中，细胞周期蛋白D1基因重排并异位表达其蛋白质产物。有丝分裂细胞周期蛋白可作为增殖细胞的标志物。
