Sund R B, Junker T, Malterud K E
Department of Pharmacology, University of Oslo, Norway.
Pharmacology. 1993 Oct;47 Suppl 1:134-7. doi: 10.1159/000139852.
Danthron infused intravenously in rats shows a complex dose-dependent pattern of metabolism and excretion. The metabolites, particularly the more polar ones, are in general excreted predominantly in bile, to a lesser extent in urine. They can be separated as metabolite groups according to polarity and molecular size on a Sephadex LH 20 column. The present paper describes a further study within a bile-derived metabolite group, which proved to be particularly heterogeneous. It contained more than a dozen metabolites, which were conjugates of four different aglycons including the parent danthron. 1H NMR spectral data for danthron monosulfate and monoglucuronide are also presented.
给大鼠静脉注射丹蒽醌后，其代谢和排泄呈现出复杂的剂量依赖性模式。代谢产物，尤其是极性较强的代谢产物，通常主要经胆汁排泄，经尿液排泄的程度较小。它们可以根据极性和分子大小在葡聚糖LH 20柱上分离为不同的代谢产物组。本文描述了对一组胆汁衍生代谢产物的进一步研究，该组代谢产物被证明特别具有异质性。它包含十几种代谢产物，是四种不同苷元（包括母体丹蒽醌）的结合物。文中还给出了单硫酸丹蒽醌和单葡萄糖醛酸丹蒽醌的1H NMR光谱数据。
