Leng-Peschlow E
Department of Pharmacology, Madaus AG, Köln, FRG.
Pharmacology. 1993 Oct;47 Suppl 1:14-21. doi: 10.1159/000139838.
The effect of oral treatment with sennosides (50 mg/kg) on the time-course of net H2O and electrolyte transport rates was studied in 1-hour incubation experiments in the rat colon in vivo. Net H2O, Na+ and Cl- absorption rates did not change during the first 4 h after treatment, but were reversed to net secretion after 6 h and partly recovered during the next 18 h. K+ and Ca2+ were secreted in controls, and net secretion increased from 6 to 24 h after treatment. Paracellular permeability of [14C]erythritol was 3-fold 6 h after treatment but unchanged at other times after treatment (2, 4, 12 or 24 h). LDH leakage into the lumen was not enhanced by treatment. Neither mucosal Na+, K(+)-ATPase activity nor cAMP or phosphodiesterase activity was affected by sennosides. As stool consistency and acceleration of transit by sennosides has entirely normalized 24 h after treatment but not net absorption of H2O and electrolytes, it is concluded that there may be regional differences in the absorptive behavior of the colon induced by sennosides. Slow transit and increased absorption in some parts of the colon may overcome secretion in other parts.
在大鼠结肠体内进行的1小时孵育实验中，研究了口服番泻苷（50毫克/千克）对净水和电解质转运速率时间进程的影响。治疗后的前4小时，净水、钠和氯的吸收速率没有变化，但6小时后转变为净分泌，并在接下来的18小时内部分恢复。对照组中钾和钙是分泌的，治疗后6至24小时净分泌增加。治疗后6小时，[14C]赤藓糖醇的细胞旁通透性增加了3倍，但在治疗后的其他时间（2、4、12或24小时）没有变化。治疗没有增强乳酸脱氢酶向肠腔的渗漏。番泻苷对黏膜钠、钾-ATP酶活性以及环磷酸腺苷或磷酸二酯酶活性均无影响。由于治疗后24小时番泻苷引起的粪便稠度和转运加速已完全恢复正常，但水和电解质的净吸收没有恢复正常，因此得出结论，番泻苷诱导的结肠吸收行为可能存在区域差异。结肠某些部位的缓慢转运和增加的吸收可能会克服其他部位的分泌。
