老年慢性便秘患者中Agiolax与乳果糖的比较。
A comparison of Agiolax and lactulose in elderly patients with chronic constipation.
作者信息
Passmore A P, Davies K W, Flanagan P G, Stoker C, Scott M G
机构信息
Department of Geriatric Medicine, Queen's University of Belfast, UK.
出版信息
Pharmacology. 1993 Oct;47 Suppl 1:249-52. doi: 10.1159/000139865.
In a double-blind crossover study the efficacies of Agiolax, a combination of fibre and senna pod, and lactulose were compared in 77 long-stay elderly patients with chronic constipation. Mean daily bowel frequency, stool consistency and ease of evacuation were significantly greater with Agiolax than lactulose. The recommended dose was exceeded more frequently with lactulose than Agiolax (chi 2 = 8.38, p < 0.01). Adverse effects were not different for the 2 treatments. In long-stay elderly patients with chronic constipation Agiolax and lactulose were well tolerated, but Agiolax proved a more effective treatment.
在一项双盲交叉研究中，对77例长期住院的慢性便秘老年患者比较了Agiolax（一种纤维与番泻叶荚的组合制剂）和乳果糖的疗效。Agiolax组患者的平均每日排便次数、大便稠度及排便难易程度均显著优于乳果糖组。乳果糖组超过推荐剂量的情况比Agiolax组更频繁（χ² = 8.38，p < 0.01）。两种治疗的不良反应无差异。对于长期住院的慢性便秘老年患者，Agiolax和乳果糖耐受性良好，但Agiolax被证明是更有效的治疗方法。
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