Berdanier C D
Department of Foods and Nutrition, University of Georgia, Athens 30602.
Prog Food Nutr Sci. 1993 Jul-Sep;17(3):261-85.
Progress in our understanding of the pathophysiology of diabetes mellitus has been made possible because of the availability of animal analogs of the various human diseases. Diabetes mellitus can be mild, moderate or severe depending on the genetic error that is responsible for the disease. Present estimates of errors that result in diabetes range from 20 to 100. Because similar errors have been found in spontaneously diabetic animals scientists have been able to identify the sequence of metabolic events and subsequent tissue change in many of these phenotypes. Studies of the efficacy of various drugs, diets and lifestyle choices on disease development and management thus were made possible.
由于存在各种人类疾病的动物类似物，我们对糖尿病病理生理学的理解取得了进展。糖尿病根据导致该疾病的基因错误不同，可分为轻度、中度或重度。目前估计导致糖尿病的错误有20到100种。由于在自发性糖尿病动物中发现了类似的错误，科学家们得以确定许多这些表型中代谢事件的顺序以及随后的组织变化。因此，关于各种药物、饮食和生活方式选择对疾病发展和管理的疗效研究成为可能。
