Pierce G N, Maddaford T G, Russell J C
Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Winnipeg, MB, Canada.
Can J Physiol Pharmacol. 1997 Apr;75(4):343-50.
Morbidity in the diabetic population is primarily a result of cardiovascular dysfunction and failure. Ischemic heart disease is a serious complication in the diabetic population. Recent data indicate that hearts from insulin-dependent models of diabetes differ significantly in their response to ischemia from hearts of models of non-insulin-dependent diabetes. Intrinsic cardiac factors may be responsible for the altered sensitivities to ischemia in the different types of diabetes. However, vascular dysfunction is also clearly present in the diabetic animal models. Endothelial cell damage and dysfunction play a prominent role in the contractile abnormalities and lesion formation during diabetes. The present treatise focuses upon insulin as a causative factor in cardiovascular disease and the differences between insulin-dependent and non-insulin-dependent models of diabetes.
糖尿病患者的发病主要是心血管功能障碍和衰竭的结果。缺血性心脏病是糖尿病患者的一种严重并发症。最近的数据表明，胰岛素依赖型糖尿病模型的心脏对缺血的反应与非胰岛素依赖型糖尿病模型的心脏有显著差异。内在心脏因素可能是不同类型糖尿病对缺血敏感性改变的原因。然而，血管功能障碍在糖尿病动物模型中也明显存在。内皮细胞损伤和功能障碍在糖尿病期间的收缩异常和病变形成中起重要作用。本论文重点关注胰岛素作为心血管疾病的致病因素以及胰岛素依赖型和非胰岛素依赖型糖尿病模型之间的差异。
