小鼠肿瘤模型中放射生物学缺氧与肿瘤氧合直接评估之间的关系
Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model.
作者信息
Horsman M R, Khalil A A, Nordsmark M, Grau C, Overgaard J
机构信息
Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus.
出版信息
Radiother Oncol. 1993 Jul;28(1):69-71. doi: 10.1016/0167-8140(93)90188-e.
PMID:8234872
Abstract
CDF1 mice were allowed to breathe either oxygen, carbogen or different concentrations of carbon monoxide gas. These treatments significantly altered the percentage of clonogenic hypoxic cells in a C3H mouse mammary carcinoma and these changes were found to correlate with direct measurements of tumour oxygenation obtained using an Eppendorf pO2 electrode.
摘要
让CDF1小鼠呼吸氧气、混合气体或不同浓度的一氧化碳气体。这些处理显著改变了C3H小鼠乳腺癌中克隆性缺氧细胞的百分比，并且发现这些变化与使用Eppendorf pO2电极获得的肿瘤氧合直接测量结果相关。
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