Fischer T, Fagerlund C, Hartvig P
Acta Derm Venereol. 1978;58(5):407-11.
The skin absorption of clioquinol and chloroquinaldol in ointment or cream base was studied in fourteen patients with widespread dermatoses. A serum concentration in the range of 0.3--1.3 microgram/ml using clioquinol and 0.05--0.1 microgram/ml with chloroquinaldol was reached by the second day and persisted throughout the topical treatment. The mean serum half-life of clioquinol and of chloroquinaldol was estimated to 25 and 6 hours, respectively. Local application of zinc oxide ointment after the end of the treatment chelate-bound the skin deposits of clioquinol and lowered the serum half-life to 11 hours. The mean daily urinary excretion of the applied amount of clioquinol and chloroquinaldol was 4.5 and 6%, respectively.
在14例患有广泛皮肤病的患者中，研究了氯碘羟喹和氯喹那多在软膏或乳膏基质中的皮肤吸收情况。使用氯碘羟喹时，第二天血清浓度达到0.3 - 1.3微克/毫升，使用氯喹那多时血清浓度达到0.05 - 0.1微克/毫升，且在整个局部治疗过程中持续存在。氯碘羟喹和氯喹那多的平均血清半衰期分别估计为25小时和6小时。治疗结束后局部应用氧化锌软膏可螯合氯碘羟喹的皮肤沉积物，并将血清半衰期降至11小时。氯碘羟喹和氯喹那多的平均每日尿排泄量分别为给药量的4.5%和6%。
