Gancel A, Lévesque H, Mabilais P, Daragon A, Courtois H
Service de Médecine Interne, Hôpital de Boisguillaume, Boisguillaume.
Rev Med Interne. 1993 May;14(5):320-2. doi: 10.1016/s0248-8663(05)81308-6.
We report a case of IgG lambda multiple myeloma with inaugural cutaneous xanthomatosis. A three years follow up showed parallel evolution of xanthomatosis and monoclonal gammapathy during therapy suggesting that the association is not coincidental. A decrease in IDL catabolism could be responsible. The monoclonal gammapathy could react with IDL and disturb the recognition of apolipoprotein E by its hepatic receptor.
我们报告一例以皮肤黄瘤病为首发表现的IgG λ型多发性骨髓瘤病例。三年的随访显示，在治疗期间黄瘤病和单克隆丙种球蛋白病呈平行进展，提示这种关联并非偶然。IDL分解代谢降低可能是原因所在。单克隆丙种球蛋白病可能与IDL发生反应，并干扰肝受体对载脂蛋白E的识别。
