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[成人阿诺德-奇亚里畸形。自磁共振成像(MRI)应用以来诊断条件的发展]

[Arnold-Chiari malformation in adults. Development of diagnostic conditions since the availability of MRI].

作者信息

Aimard G, Petiot P, Confavreux C, Vighetto A, Froment J C, Croisile B, Charles N, Trillet M

机构信息

Service de Neurologie, Hôpital Neurologique Pierre Wertheimer, Lyon.

出版信息

Rev Neurol (Paris). 1993;149(3):227-30.

PMID:8235220
Abstract

We reviewed retrospectively 47 patients with a Chiari malformation (CM) who had been admitted to the Clinique de Neurologie of Lyon from 1971 to 1991. The purpose of this report is to assess the possible influence on the frequency and the clinical pattern at presentation of CM since 1985 when Magnetic Resonance Imaging (MRI) became available to us. A diagnosis of CM was made for 21 patients before 1985 (group 1) and for 26 patients thereafter (group 2), i.e., a 2.5 increase of incidence of CM frequency (1.5 patients/year before 1985 vs 3.7 patients/year thereafter). This increase was even more striking for cases without syringomyelic symptoms and signs (SSS) (42.9% in group 1, vs 76.9% in group 2). The accuracy of clinical diagnosis was 68.1% for the total surveyed period (90.5% before 1985 and 50% thereafter). For cases with SS at presentation, a syringomyelic cavity was radiologically demonstrated in 80% of the cases in the pre-MRI period and 90.9% of the cases since MRI was available. On the other hand, when a syringomyelic cavity was radiologically demonstrated, there was a related clinical SS in 70% of group 1 patients and 50% of group 2 patients.

摘要

我们回顾性研究了1971年至1991年间收治于里昂神经科诊所的47例Chiari畸形(CM)患者。本报告的目的是评估自1985年我们能够使用磁共振成像(MRI)以来,其对CM发病频率及临床表现模式可能产生的影响。1985年前诊断出CM的患者有21例(第1组),之后有26例(第2组),即CM发病率增加了2.5倍(1985年前为每年1.5例,之后为每年3.7例)。对于无脊髓空洞症症状和体征(SSS)的病例,这种增加更为显著(第1组为42.9%,第2组为76.9%)。在整个调查期间,临床诊断的准确率为68.1%(1985年前为90.5%,之后为50%)。对于就诊时有脊髓空洞症(SS)的病例,在MRI应用前,80%的病例影像学显示有脊髓空洞症腔,MRI应用后这一比例为90.9%。另一方面,当影像学显示有脊髓空洞症腔时,第1组70%的患者和第2组50%的患者有相关的临床SS。

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