弥漫性大细胞淋巴瘤中锌指编码基因BCL-6的改变。
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.
作者信息
Ye B H, Lista F, Lo Coco F, Knowles D M, Offit K, Chaganti R S, Dalla-Favera R
机构信息
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
出版信息
Science. 1993 Oct 29;262(5134):747-50. doi: 10.1126/science.8235596.
The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.
弥漫性大细胞淋巴瘤（DLCL）是最常见且临床上具有相关性的淋巴瘤类型，其分子发病机制尚不清楚。从影响3q27带的染色体易位中克隆出一个基因，这种易位在DLCL中很常见。这个基因，即BCL-6，编码一种与锌指转录因子同源的79千道尔顿蛋白。在33%（39个样本中的13个）的DLCL样本中，但在其他类型的淋巴恶性肿瘤中未发现，BCL-6基因在其5'非编码序列内被截断，这表明其表达失调。因此，BCL-6可能是一个专门参与DLCL发病机制的原癌基因。
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