Effect of estrogen on activity of prostaglandin synthetase in rabbit oviduct.

The activity of the prostaglandin synthetase system in the ampulla and isthmus of the rabbit oviduct has been studied in vitro. Thirty hours after an injection of estrogen the isthmus produced significantly more total prostaglandins following 9 minutes of incubation than the ampulla. These values were not, however, significantly different from those observed following 9 minutes of incubation in the same portions of the oviducts of estrous or castrate animals. Furthermore, the total yields of prostaglandins at thirty minutes did not differ significantly between treatment groups.