Maia H, Barbosa I, Harper M J, Hodgson B J, Pauerstein C J
Fertil Steril. 1977 Jan;28(1):91-5.
Rabbit oviductal circular muscle isometric contractile response was measured in relation to treatment with prostaglandin E1 (PGE1) and prostaglandin F2alpha (PGF2alpha). PGE1 (1 mug/ml) inhibition of the contractile response of the rabbit oviduct to field stimulation was increased in the proximal isthmus after ovulation. Estrogen and progesteron, in doses known to alter ovum transport, did not affect the response of the oviduct to PGE1. In comparison to the response of estrous tissues, the stimulatory effect of PGF2alpha on the isthmus was decreased 24 hours after administration of human chorionic gonadotropin (HCG). Treatment with estrogen and progesterone did not affect these postovulatory changes. The response of the ampullary-isthmic junction to PGF2alpha was significantly reduced 72 hours after administration of HCG. Neither ovulation nor steroid treatment affected the response of the ampulla to PGF2alpha. Changes in the sensitivity of the oviduct to prostaglandins after ovulation may be necessary for successful ovum transport.
测定了兔输卵管环形肌的等长收缩反应与前列腺素E1（PGE1）和前列腺素F2α（PGF2α）处理的关系。排卵后，在近端峡部，PGE1（1微克/毫升）对兔输卵管对场刺激的收缩反应的抑制作用增强。已知能改变卵子运输的雌激素和孕酮剂量，并不影响输卵管对PGE1的反应。与发情期组织的反应相比，人绒毛膜促性腺激素（HCG）给药24小时后，PGF2α对峡部的刺激作用减弱。雌激素和孕酮处理不影响这些排卵后的变化。HCG给药72小时后，壶腹-峡部连接处对PGF2α的反应显著降低。排卵和类固醇处理均不影响壶腹部对PGF2α的反应。排卵后输卵管对前列腺素敏感性的变化可能是卵子成功运输所必需的。
