Bevilacqua M P, Nelson R M
Department of Pathology, University of California San Diego, La Jolla.
Thromb Haemost. 1993 Jul 1;70(1):152-4.
Vascular endothelium is an active tissue. In response to various mediators, it expresses specific cell surface glycoproteins that support the binding and extravasation of blood leukocytes. These events are essential for host defense against pathogens and for repair of tissue damage. Unfortunately, it appears that a number of blood borne tumor cells may be able to use the same adhesive structures to facilitate their metastasis. The development of agents designed to block the adhesion of leukocytes (or tumor cells) to the vessel wall may prove valuable in the treatment of a variety of human disease processes, including adult respiratory distress syndrome (ARDS), ischemic reperfusion injury, autoimmunity, and metastatic spread of cancer.
血管内皮是一种活跃的组织。响应各种介质时，它会表达特定的细胞表面糖蛋白，这些糖蛋白支持血液白细胞的黏附和外渗。这些过程对于宿主抵御病原体和组织损伤修复至关重要。不幸的是，似乎许多血源性肿瘤细胞可能能够利用相同的黏附结构来促进其转移。设计用于阻断白细胞（或肿瘤细胞）与血管壁黏附的药物，可能在治疗多种人类疾病过程中具有价值，包括成人呼吸窘迫综合征（ARDS）、缺血再灌注损伤、自身免疫以及癌症的转移扩散。
